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2020

Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2

Chen, H. Y., Wang, M. L., Laurent, B., Hsu, D. C. H., Chen, M. T., Lin, L. T., Shen, J., Chang, W. C., Hsu, J., Hung, M. C., Chen, Y. W., Huang, P. I., Yang, Y. P., Li, C. P., Ma, H. I., Chen, C. H., Lin, W. C. & Chiou, S. H., Jan 1 2020, In : Theranostics. 10, 1, p. 201-217 17 p.

Research output: Contribution to journalArticle

Open Access
Neoplasms
Cytosol
Cell Fractionation
Recurrence
Messenger RNA

Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells

Pataer, A., Ozpolat, B., Shao, R. P., Cashman, N. R., Plotkin, S. S., Samuel, C. E., Lin, S. H., Kabil, N. N., Wang, J., Majidi, M., Fang, B., Roth, J. A., Vaporciyan, A. A., Wistuba, I. I., Hung, M. C. & Swisher, S. G., Jan 23 2020, In : Oncogene. 39, 4, p. 801-813 13 p.

Research output: Contribution to journalArticle

Lysosomes
Protein Kinases
Survival
Neoplasms
Proteins
2019
Sarcoma
Ascorbic Acid
Growth
Neoplasms
Oxidative Stress

Activation of Aurora A kinase increases YAP stability via blockage of autophagy

Wang, P., Gong, Y., Guo, T., Li, M., Fang, L., Yin, S., Kamran, M., Liu, Y., Xu, J., Xu, L., Peng, F., Xue, X., Yang, M., Hung, M. C., Lam, E. W. F., Gu, C., Wang, C., Zhan, Q. & Liu, Q., Jun 1 2019, In : Cell Death and Disease. 10, 6, 432.

Research output: Contribution to journalArticle

Open Access
Aurora Kinase A
Protein Stability
Autophagy
Proteins
Lung Neoplasms

ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis

Lin, Q., Chen, X., Meng, F., Ogawa, K., Li, M., Song, R., Zhang, S., Zhang, Z., Kong, X., Xu, Q., He, F., Bai, X., Sun, B., Hung, M. C., Liu, L., Wands, J. & Dong, X., Nov 7 2019, In : Molecular cancer. 18, 1, 156.

Research output: Contribution to journalArticle

Open Access
Mixed Function Oxygenases
Aspartic Acid
Breast Neoplasms
Neoplasm Metastasis
Exosomes
2 Citations (Scopus)

Assessing metastatic potential of breast cancer cells based on EGFR dynamics

Liu, Y. L., Chou, C. K., Kim, M., Vasisht, R., Kuo, Y. A., Ang, P., Liu, C., Perillo, E. P., Chen, Y. A., Blocher, K., Horng, H., Chen, Y. I., Nguyen, D. T., Yankeelov, T. E., Hung, M. C., Dunn, A. K. & Yeh, H. C., Dec 1 2019, In : Scientific reports. 9, 1, 3395.

Research output: Contribution to journalArticle

Open Access
Epidermal Growth Factor Receptor
Breast Neoplasms
Cell Membrane
Neoplasms
MCF-7 Cells

BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress

Chen, F. Y., Huang, M. Y., Lin, Y. M., Ho, C. H., Lin, S. Y., Chen, H. Y., Hung, M. C. & Chen, R. H., Sep 2 2019, In : The Journal of cell biology. 218, 9, p. 3002-3018 17 p.

Research output: Contribution to journalArticle

Open Access
Ubiquitin-Protein Ligases
Ubiquitination
Unfolded Protein Response
Apoptosis Regulatory Proteins
Proteasome Endopeptidase Complex

CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Nie, L., Wei, Y., Zhang, F., Hsu, Y. H., Chan, L. C., Xia, W., Ke, B., Zhu, C., Deng, R., Tang, J., Yao, J., Chu, Y. Y., Zhao, X., Han, Y., Hou, J., Huo, L., Ko, H. W., Lin, W. C., Yamaguchi, H., Hsu, J. M. & 7 others, Yang, Y., Pan, D. N., Hsu, J. L., Kleer, C. G., Davidson, N. E., Hortobagyi, G. N. & Hung, M. C., Dec 1 2019, In : Nature communications. 10, 1, 5114.

Research output: Contribution to journalArticle

Open Access
Cyclin-Dependent Kinase 2
Triple Negative Breast Neoplasms
phosphorylation
Phosphorylation
breast

Correction: Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer (Oncogene, (2016), 35, 12, (1517-1528), 10.1038/onc.2015.214)

Chang, Y. W., Tseng, C. F., Wang, M. Y., Chang, W. C., Lee, C. C., Chen, L. T., Hung, M. C. & Su, J. L., Jan 1 2019, (Accepted/In press) In : Oncogene.

Research output: Contribution to journalComment/debate

Open Access
Ficus
Ubiquitination
Oncogenes
Western Blotting
Breast Neoplasms
9 Citations (Scopus)

Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade

Zhu, Y., Yang, J., Xu, D., Gao, X. M., Zhang, Z., Hsu, J. L., Li, C. W., Lim, S. O., Sheng, Y. Y., Zhang, Y., Li, J. H., Luo, Q., Zheng, Y., Zhao, Y., Lu, L., Jia, H. L., Hung, M. C., Dong, Q. Z. & Qin, L. X., Sep 1 2019, In : Gut. 68, 9, p. 1653-1666 14 p.

Research output: Contribution to journalArticle

Osteopontin
Macrophage Colony-Stimulating Factor
Hepatocellular Carcinoma
Macrophages
Ligands
1 Citation (Scopus)

EGFR and c-Met cooperate to enhance resistance to PARP inhibitors in hepatocellular carcinoma

Dong, Q., Du, Y., Li, H., Liu, C., Wei, Y., Chen, M. K., Zhao, X., Chu, Y. Y., Qiu, Y., Qin, L., Yamaguchi, H. & Hung, M. C., Feb 15 2019, In : Cancer research. 79, 4, p. 819-829 11 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Ovarian Neoplasms
Poly(ADP-ribose) Polymerase Inhibitors
Therapeutics
Biomarkers

Erratum: Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with β-blockers (Science Translational Medicine DOI: 10.1126/scitranslmed.aao4307)

Nilsson, M. B., Sun, H., Diao, L., Tong, P., Liu, D., Li, L., Fan, Y., Poteete, A., Lim, S. O., Howells, K., Haddad, V., Gomez, D., Tran, H., Pena, G. A., Sequist, L. V., Yang, J. C., Wang, J., Kim, E. S., Herbst, R., Lee, J. J. & 5 others, Hong, W. K., Wistuba, I., Hung, M. C., Sood, A. K. & Heymach, J. V., May 22 2019, In : Science Translational Medicine. 11, 493, eaax9987.

Research output: Contribution to journalComment/debate

Translational Medical Research
Hormones
Research
Eukaryotic Initiation Factor-2
Endoplasmic Reticulum
Protein Kinases
Adenocarcinoma
Phosphotransferases
1 Citation (Scopus)

Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology

Lee, H. H., Wang, Y. N. & Hung, M. C., Dec 2019, In : Molecular Aspects of Medicine. 70, p. 106-116 11 p.

Research output: Contribution to journalReview article

Pancreatic Ribonuclease
Ribonucleases
Metabolism
RNA
Membranes

H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism

Chen, M. K., Du, Y., Sun, L., Hsu, J. L., Wang, Y. H., Gao, Y., Huang, J. & Hung, M. C., Jan 1 2019, In : Journal of Biological Chemistry. 294, 21, p. 8516-8528 13 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Receptor Protein-Tyrosine Kinases
Cytoplasmic and Nuclear Receptors
Protein-Tyrosine Kinases
Reactive Oxygen Species
4 Citations (Scopus)

IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion

Chan, L. C., Li, C. W., Xia, W., Hsu, J. M., Lee, H. H., Cha, J. H., Wang, H. L., Yang, W. H., Yen, E. Y., Chang, W. C., Zha, Z., Lim, S. O., Lai, Y. J., Liu, C., Liu, J., Dong, Q., Yang, Y., Sun, L., Wei, Y., Nie, L. & 9 others, Hsu, J. L., Li, H., Ye, Q., Hassan, M. M., Amin, H. M., Kaseb, A. O., Lin, X., Wang, S. C. & Hung, M. C., Aug 1 2019, In : Journal of Clinical Investigation. 129, 8, p. 3324-3338 15 p.

Research output: Contribution to journalArticle

Open Access
Immune Evasion
Interleukin-6
Phosphorylation
Ligands
Glycosylation
7 Citations (Scopus)

LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition

Hu, Q., Li, C., Wang, S., Li, Y., Wen, B., Zhang, Y., Liang, K., Yao, J., Ye, Y., Hsiao, H., Nguyen, T. K., Park, P. K., Egranov, S. D., Hawke, D. H., Marks, J. R., Han, L., Hung, M. C., Zhang, B., Lin, C. & Yang, L., Apr 1 2019, In : Cell research. 29, 4, p. 286-304 19 p.

Research output: Contribution to journalArticle

Phosphoprotein Phosphatases
Long Noncoding RNA
PTEN Phosphohydrolase
Protein Tyrosine Phosphatases
Phosphatidylinositols

Mechanisms Controlling PD-L1 Expression in Cancer

Cha, J. H., Chan, L. C., Li, C. W., Hsu, J. L. & Hung, M. C., Nov 7 2019, In : Molecular cell. 76, 3, p. 359-370 12 p.

Research output: Contribution to journalReview article

Open Access
Neoplasms
T-Lymphocytes
Programmed Cell Death 1 Receptor
Ligands
Immunotherapy
10 Citations (Scopus)

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1

Li, H., Li, C. W., Li, X., Ding, Q., Guo, L., Liu, S., Liu, C., Lai, C. C., Hsu, J. M., Dong, Q., Xia, W., Hsu, J. L., Yamaguchi, H., Du, Y., Lai, Y. J., Sun, X., Koller, P. B., Ye, Q. & Hung, M. C., May 2019, In : Gastroenterology. 156, 6, p. 1849-1861.e13

Research output: Contribution to journalArticle

Tumor Escape
Liver Neoplasms
Ligands
Liver
Neoplasms
14 Citations (Scopus)

Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications

Ju, H. Q., Lu, Y. X., Chen, D. L., Zuo, Z. X., Liu, Z. X., Wu, Q. N., Mo, H. Y., Wang, Z. X., Wang, D. S., Pu, H. Y., Zeng, Z. L., Li, B., Xie, D., Huang, P., Hung, M. C., Chiao, P. J. & Xu, R. H., Jun 1 2019, In : Journal of the National Cancer Institute. 111, 6, p. 584-596 13 p.

Research output: Contribution to journalArticle

Open Access
Tetrahydrofolate Dehydrogenase
Oxidation-Reduction
Colorectal Neoplasms
Homeostasis
Therapeutics
9 Citations (Scopus)

Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression

Hu, Q., Ye, Y., Chan, L. C., Li, Y., Liang, K., Lin, A., Egranov, S. D., Zhang, Y., Xia, W., Gong, J., Pan, Y., Chatterjee, S. S., Yao, J., Evans, K. W., Nguyen, T. K., Park, P. K., Liu, J., Coarfa, C., Donepudi, S. R., Putluri, V. & 17 others, Putluri, N., Sreekumar, A., Ambati, C. R., Hawke, D. H., Marks, J. R., Gunaratne, P. H., Caudle, A. S., Sahin, A. A., Hortobagyi, G. N., Meric-Bernstam, F., Chen, L., Yu, D., Hung, M. C., Curran, M. A., Han, L., Lin, C. & Yang, L., Jul 1 2019, In : Nature Immunology. 20, 7, p. 835-851 17 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Triple Negative Breast Neoplasms
Antigen Presentation
Human Mammary Glands
Down-Regulation
7 Citations (Scopus)

Palmitoylation stabilizes PD-L1 to promote breast tumor growth

Yang, Y., Hsu, J. M., Sun, L., Chan, L. C., Li, C. W., Hsu, J. L., Wei, Y., Xia, W., Hou, J., Qiu, Y. & Hung, M. C., Jan 1 2019, In : Cell research. 29, 1, p. 83-86 4 p.

Research output: Contribution to journalLetter

Lipoylation
Breast Neoplasms
Growth
4 Citations (Scopus)

PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease

Li, Y., Hu, Q., Li, C., Liang, K., Xiang, Y., Hsiao, H., Nguyen, T. K., Park, P. K., Egranov, S. D., Ambati, C. R., Putluri, N., Hawke, D. H., Han, L., Hung, M. C., Danesh, F. R., Yang, L. & Lin, C., Mar 2019, In : Journal of Clinical Investigation. 129, 3, p. 1129-1151 23 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Diabetic Nephropathies
Phosphoric Monoester Hydrolases
Kidney
Streptozocin
7 Citations (Scopus)

PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression

Park, M. K., Yao, Y., Xia, W., Setijono, S. R., Kim, J. H., Vila, I. K., Chiu, H. H., Wu, Y., Billalabeitia, E. G., Lee, M. G., Kalb, R. G., Hung, M. C., Pandolfi, P. P., Song, S. J. & Song, M. S., Dec 1 2019, In : Nature communications. 10, 1, 636.

Research output: Contribution to journalArticle

Open Access
Phosphatidylinositol 3-Kinases
Tumors
tumors
retarding
Neoplasms
1 Citation (Scopus)

Racial profiling harms science

Lu, S., Han, Z., Hung, M-C., Xu, J., Xu, Y., Zheng, P., Zheng, Z. M., Zou, L., Li, Z., Zheng, L., Kang, Y., Yang, Y., He, L., Liao, X. C., Yu, H., Yue, Z., Liu, S. L. & Zheng, H., Mar 22 2019, In : Science. 363, 6433, p. 1290-1292 3 p.

Research output: Contribution to journalLetter

Racism
China
6 Citations (Scopus)

Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy

Lee, H. H., Wang, Y. N., Xia, W., Chen, C. H., Rau, K. M., Ye, L., Wei, Y., Chou, C. K., Wang, S. C., Yan, M., Tu, C. Y., Hsia, T. C., Chiang, S. F., Chao, K. S. C., Wistuba, I. I., Hsu, J. L., Hortobagyi, G. N. & Hung, M. C., Aug 12 2019, In : Cancer cell. 36, 2, p. 168-178.e4

Research output: Contribution to journalArticle

Glycosylation
Leukocyte L1 Antigen Complex
Antibody Affinity
Therapeutics
Surface Antigens

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Houl, J. H., Ye, Z., Brosey, C. A., Balapiti-Modarage, L. P. F., Namjoshi, S., Bacolla, A., Laverty, D., Walker, B. L., Pourfarjam, Y., Warden, L. S., Babu Chinnam, N., Moiani, D., Stegeman, R. A., Chen, M. K., Hung, M. C., Nagel, Z. D., Ellenberger, T., Kim, I. K., Jones, D. E., Ahmed, Z. & 1 others, Tainer, J. A., Dec 1 2019, In : Nature communications. 10, 1, 5654.

Research output: Contribution to journalArticle

Open Access
stalling
ribose
adenosine diphosphate
forks
Cell death

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

Li, N., Wang, Y., Neri, S., Zhen, Y., Fong, L. W. R., Qiao, Y., Li, X., Chen, Z., Stephan, C., Deng, W., Ye, R., Jiang, W., Zhang, S., Yu, Y., Hung, M. C., Chen, J. & Lin, S. H., Dec 1 2019, In : Nature communications. 10, 1, 4363.

Research output: Contribution to journalArticle

Open Access
Tankyrases
homeostasis
AMP-Activated Protein Kinases
metabolic diseases
Carcinogenesis
2018
28 Citations (Scopus)

Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice

Peng, J. M., Bera, R., Chiou, C. Y., Yu, M. C., Chen, T. C., Chen, C. W., Wang, T. R., Chiang, W. L., Chai, S. P., Wei, Y., Wang, H., Hung, M. C. & Hsieh, S. Y., Jun 2018, In : Hepatology. 67, 6, p. 2226-2243 18 p.

Research output: Contribution to journalArticle

Epithelial-Mesenchymal Transition
Actin Cytoskeleton
Hepatocellular Carcinoma
Neoplasm Metastasis
Actins
3 Citations (Scopus)

Activation of phagocytosis by immune checkpoint blockade

Li, C. W., Lai, Y. J., Hsu, J. L. & Hung, M. C., Aug 1 2018, In : Frontiers of Medicine. 12, 4, p. 473-480 8 p.

Research output: Contribution to journalReview article

Phagocytosis
Macrophages
Neoplasms
Tumor Escape
Tumor Microenvironment
2 Citations (Scopus)

A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues

Chou, C. K., Huang, P. J., Tsou, P. H., Wei, Y., Lee, H. H., Wang, Y. N., Liu, Y. L., Shi, C., Yeh, H. C., Kameoka, J. & Hung, M. C., Oct 15 2018, In : Biosensors and Bioelectronics. 117, p. 97-103 7 p.

Research output: Contribution to journalArticle

Tissue
Proteins
Western Blotting
Immunohistochemistry
Neoplasms
4 Citations (Scopus)

A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing

Zhou, R., Xu, A., Wang, D., Zhu, D., Mata, H., Huo, Z., Tu, J., Liu, M., Mohamed, A. M. T., Jewell, B. E., Gingold, J., Xia, W., Rao, P. H., Hung, M. C., Zhao, R. & Lee, D. F., Mar 2018, In : Stem Cell Research. 27, p. 131-135 5 p.

Research output: Contribution to journalArticle

Cell Line
Germ Layers
Mutation
Teratoma
Tumor Suppressor Genes
8 Citations (Scopus)

Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer

Wang, Y. N., Lee, H. H., Chou, C. K., Yang, W. H., Wei, Y., Chen, C. T., Yao, J., Hsu, J. L., Zhu, C., Ying, H., Ye, Y., Wang, W. J., Lim, S. O., Xia, W., Ko, H. W., Liu, X., Liu, C. G., Wu, X., Wang, H., Li, D. & 9 others, Prakash, L. R., Katz, M. H., Kang, Y., Kim, M., Fleming, J. B., Fogelman, D., Javle, M., Maitra, A. & Hung, M. C., Apr 9 2018, In : Cancer cell. 33, 4, p. 752-769.e8

Research output: Contribution to journalArticle

Pancreatic Neoplasms
Epidermal Growth Factor Receptor
Biomarkers
Ligands
Serum
1 Citation (Scopus)

A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases

Wang, Y. N., Lee, H. H. & Hung, M. C., Nov 19 2018, In : Journal of biomedical science. 25, 1, 1 p.

Research output: Contribution to journalReview article

Receptor Protein-Tyrosine Kinases
Ribonucleases
Epidermal Growth Factor Receptor
Ligands
Pancreatic Ribonuclease
45 Citations (Scopus)

BAP1 links metabolic regulation of ferroptosis to tumour suppression

Zhang, Y., Shi, J., Liu, X., Feng, L., Gong, Z., Koppula, P., Sirohi, K., Li, X., Wei, Y., Lee, H., Zhuang, L., Chen, G., Xiao, Z. D., Hung, M. C., Chen, J., Huang, P., Li, W. & Gan, B., Oct 1 2018, In : Nature cell biology. 20, 10, p. 1181-1192 12 p.

Research output: Contribution to journalArticle

BRCA1 Protein
Neoplasms
Cystine
Ubiquitination
Epigenomics
1 Citation (Scopus)

CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line?

Yam, C., Hung, M. C. & Hortobagyi, G. N., Sep 1 2018, In : Oncotarget. 9, 76, p. 34193-34195 3 p.

Research output: Contribution to journalEditorial

Hormones
Breast Neoplasms
human ERBB2 protein
61 Citations (Scopus)

Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1

Li, C. W., Lim, S. O., Chung, E. M., Kim, Y. S., Park, A. H., Yao, J., Cha, J. H., Xia, W., Chan, L. C., Kim, T., Chang, S. S., Lee, H. H., Chou, C. K., Liu, Y. L., Yeh, H. C., Perillo, E. P., Dunn, A. K., Kuo, C. W., Khoo, K. H., Hsu, J. L. & 8 others, Wu, Y., Hsu, J. M., Yamaguchi, H., Huang, T. H., Sahin, A. A., Hortobagyi, G. N., Yoo, S. S. & Hung, M. C., Feb 12 2018, In : Cancer cell. 33, 2, p. 187-201.e10

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Ligands
Glycosylation
CD274 Antigen
Immunosuppression
4 Citations (Scopus)

Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing

Xu, A., Zhou, R., Tu, J., Huo, Z., Zhu, D., Wang, D., Gingold, J. A., Mata, H., Rao, P. H., Liu, M., Mohamed, A. M. T., Kong, C. S. L., Jewell, B. E., Xia, W., Zhao, R., Hung, M. C. & Lee, D. F., May 2018, In : Stem Cell Research. 29, p. 215-219 5 p.

Research output: Contribution to journalArticle

Cell Line
Germ Layers
Mutation
Karyotype
Gene Expression
24 Citations (Scopus)

Exosomal PD-L1 harbors active defense function to suppress t cell killing of breast cancer cells and promote tumor growth

Yang, Y., Li, C. W., Chan, L. C., Wei, Y., Hsu, J. M., Xia, W., Cha, J. H., Hou, J., Hsu, J. L., Sun, L. & Hung, M. C., Aug 1 2018, In : Cell research. 28, 8, p. 862-864 3 p.

Research output: Contribution to journalLetter

Breast Neoplasms
Growth
Neoplasms
9 Citations (Scopus)

Expression of long noncoding RNA YIYA promotes glycolysis in breast cancer

Xing, Z., Zhang, Y., Liang, K., Yan, L., Xiang, Y., Li, C., Hu, Q., Jin, F., Putluri, V., Putluri, N., Coarfa, C., Sreekumar, A., Park, P. K., Nguyen, T. K., Wang, S., Zhou, J., Zhou, Y., Marks, J. R., Hawke, D. H., Hung, M-C. & 4 others, Yang, L., Han, L., Ying, H. & Lin, C., Aug 15 2018, In : Cancer research. 78, 16, p. 4524-4532 9 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Glycolysis
Breast Neoplasms
Neoplasms
Clustered Regularly Interspaced Short Palindromic Repeats
16 Citations (Scopus)

EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer

Yamaguchi, H., Du, Y., Nakai, K., Ding, M., Chang, S. S., Hsu, J. L., Yao, J., Wei, Y., Nie, L., Jiao, S., Chang, W. C., Chen, C. H., Yu, Y., Hortobagyi, G. N. & Hung, M. C., Jan 11 2018, In : Oncogene. 37, 2, p. 208-217 10 p.

Research output: Contribution to journalArticle

Poly(ADP-ribose) Polymerases
Adenosine Diphosphate
Breast Neoplasms
Ovarian Neoplasms
DNA Damage

Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation

Jewell, B. E., Liu, M., Lu, L., Zhou, R., Tu, J., Zhu, D., Huo, Z., Xu, A., Wang, D., Mata, H., Jin, W., Xia, W., Rao, P. H., Zhao, R., Hung, M. C., Wang, L. L. & Lee, D. F., Dec 2018, In : Stem Cell Research. 33, p. 36-40 5 p.

Research output: Contribution to journalArticle

DNA Helicases
Induced Pluripotent Stem Cells
Rothmund-Thomson Syndrome
Cell Line
Germ Layers
9 Citations (Scopus)

HIF-1α promotes autophagic proteolysis of dicer and enhances tumor metastasis

Lai, H. H., Li, J. N., Wang, M. Y., Huang, H. Y., Croce, C. M., Sun, H. L., Lyu, Y. J., Kang, J. W., Chiu, C. F., Hung, M. C., Suzuki, H. I. & Chen, P. S., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 625-643 19 p.

Research output: Contribution to journalArticle

Proteolysis
Neoplasm Metastasis
Neoplasms
Ubiquitination
MicroRNAs
2 Citations (Scopus)

Juxtacrine signaling inhibits antitumor immunity by upregulating PD-L1 expression

Yang, W. H., Cha, J. H., Xia, W., Lee, H. H., Chan, L. C., Wang, Y. N., Hsu, J. L., Ren, G. & Hung, M. C., Jul 15 2018, In : Cancer research. 78, 14, p. 3761-3768 8 p.

Research output: Contribution to journalArticle

Immunity
Ligands
Eph Family Receptors
antineoplaston A10
Neoplasms
5 Citations (Scopus)

Linear ubiquitination of cFLIP induced by LUBAC contributes to TNF-induced apoptosis

Tang, Y., Joo, D., Liu, G., Tu, H., You, J., Jin, J., Zhao, X., Hung, M. C. & Lin, X., Jan 1 2018, In : Journal of Biological Chemistry. 293, 52, p. 20062-20072 11 p.

Research output: Contribution to journalArticle

CASP8 and FADD-Like Apoptosis Regulating Protein
Ubiquitination
Ubiquitin
Tumor Necrosis Factor-alpha
Apoptosis
52 Citations (Scopus)

Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Kim, J., Piao, H. L., Kim, B. J., Yao, F., Han, Z., Wang, Y., Xiao, Z., Siverly, A. N., Lawhon, S. E., Ton, B. N., Lee, H., Zhou, Z., Gan, B., Nakagawa, S., Ellis, M. J., Liang, H., Hung, M. C., You, M. J., Sun, Y. & Ma, L., Dec 1 2018, In : Nature Genetics. 50, 12, p. 1705-1715 11 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Breast Neoplasms
Neoplasm Metastasis
Gene Silencing
Heterografts
53 Citations (Scopus)

Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1

Cha, J. H., Yang, W. H., Xia, W., Wei, Y., Chan, L. C., Lim, S. O., Li, C. W., Kim, T., Chang, S. S., Lee, H. H., Hsu, J. L., Wang, H. L., Kuo, C. W., Chang, W. C., Hadad, S., Purdie, C. A., McCoy, A. M., Cai, S., Tu, Y., Litton, J. K. & 8 others, Mittendorf, E. A., Moulder, S. L., Symmans, W. F., Thompson, A. M., Piwnica-Worms, H., Chen, C. H., Khoo, K. H. & Hung, M. C., Aug 16 2018, In : Molecular cell. 71, 4, p. 606-620.e7

Research output: Contribution to journalArticle

Endoplasmic Reticulum-Associated Degradation
Metformin
Immunity
Ligands
AMP-Activated Protein Kinases
1 Citation (Scopus)

Mutant LKB1 confers enhanced radiosensitization in combination with trametinib in KRAS-mutant non–small cell lung cancer

Wang, Y., Li, N., Jiang, W., Deng, W., Ye, R., Xu, C., Qiao, Y., Sharma, A., Zhang, M., Hung, M. C. & Lin, S. H., Nov 15 2018, In : Clinical Cancer Research. 24, 22, p. 5744-5756 13 p.

Research output: Contribution to journalArticle

Non-Small Cell Lung Carcinoma
Autophagy
AMP-Activated Protein Kinases
trametinib
Radiotherapy
19 Citations (Scopus)

Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function

Wan, L., Xu, K., Wei, Y., Zhang, J., Han, T., Fry, C., Zhang, Z., Wang, Y. V., Huang, L., Yuan, M., Xia, W., Chang, W. C., Huang, W. C., Liu, C. L., Chang, Y. C., Liu, J., Wu, Y., Jin, V. X., Dai, X., Guo, J. & 7 others, Liu, J., Jiang, S., Li, J., Asara, J. M., Brown, M., Hung, M. C. & Wei, W., Jan 18 2018, In : Molecular cell. 69, 2, p. 279-291.e5

Research output: Contribution to journalArticle

Polycomb Repressive Complex 2
AMP-Activated Protein Kinases
Methyltransferases
Phosphorylation
Histone Code
10 Citations (Scopus)

Posttranslational modifications of PD-L1 and their applications in cancer therapy

Hsu, J. M., Li, C. W., Lai, Y. J. & Hung, M. C., Nov 15 2018, In : Cancer research. 78, 22, p. 6349-6353 5 p.

Research output: Contribution to journalArticle

Post Translational Protein Processing
Sumoylation
Neoplasms
Protein Stability
Ubiquitination