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2019

ASO Author Reflections: An Optimal Biological Model for Successful Drug Discovery

Jordan, V. C., Jul 15 2019, In : Annals of surgical oncology. 26, 7, p. 1991-1992 2 p.

Research output: Contribution to journalComment/debate

Biological Models
Drug Discovery
1 Citation (Scopus)

Estrogen-induced apoptosis in breast cancers is phenocopied by blocking dephosphorylation of eukaryotic initiation factor 2 alpha (eIF2α) protein

Sengupta, S., Sevigny, C. M., Bhattacharya, P., Jordan, V. C. & Clarke, R., Jan 1 2019, In : Molecular Cancer Research. 17, 4, p. 918-928 11 p.

Research output: Contribution to journalArticle

Eukaryotic Initiation Factor-2
Estrogens
Apoptosis
Breast Neoplasms
Proteins
1 Citation (Scopus)

Suppression of nuclear factor-kB by glucocorticoid receptor blocks estrogen-induced apoptosis in estrogen-deprived breast cancer cells

Fan, P., Siwak, D. R., Abderrahman, B., Agboke, F. A., Yerrum, S. & Jordan, V. C., Jan 1 2019, In : Molecular cancer therapeutics. 18, 10, p. 1684-1695 12 p.

Research output: Contribution to journalArticle

Open Access
Glucocorticoid Receptors
Fatty Acid Desaturases
Estrogens
Dexamethasone
Apoptosis
2 Citations (Scopus)

Tamoxifen metabolism and breast cancer recurrence: A question unanswered by CYPTAM

Goetz, M. P., Suman, V. J., Nakamura, Y., Kiyotani, K., Jordan, V. C. & Ingle, J. N., Aug 1 2019, In : Journal of Clinical Oncology. 37, 22, p. 1982-1983 2 p.

Research output: Contribution to journalLetter

Tamoxifen
Breast Neoplasms
Recurrence
1 Citation (Scopus)
Selective Estrogen Receptor Modulators
Tamoxifen
Estrogen Receptor Modulators
Neoplasms
Orphan Drug Production
2018
3 Citations (Scopus)

A unifying biology of sex steroid-induced apoptosis in prostate and breast cancers

Maximov, P. Y., Abderrahman, B., Curpan, R. F., Hawsawi, Y. M., Fan, P. & Jordan, V. C., Feb 2018, In : Endocrine-Related Cancer. 25, 2, p. R83-R113

Research output: Contribution to journalReview article

Prostatic Neoplasms
Steroids
Apoptosis
Breast Neoplasms
Therapeutics

Correction: Buthionine sulfoximine sensitizes antihormone-resistant human breast cancer cells to estrogen-induced apoptosis [Breast Cancer Res., 10, (2008) (R104)] DOI: 10.1186/bcr2208

Lewis-Wambi, J. S., Kim, H. R., Wambi, C., Patel, R., Pyle, J. R., Klein-Szanto, A. J. & Craig Jordan, V., Jun 14 2018, In : Breast Cancer Research. 20, 1, 57.

Research output: Contribution to journalComment/debate

Buthionine Sulfoximine
Publications
Estrogens
Apoptosis
Breast Neoplasms
3 Citations (Scopus)

Endoxifen, 4-hydroxytamoxifen and an estrogenic derivative modulate estrogen receptor complex mediated apoptosis in breast cancer

Maximov, P. Y., Abderrahman, B., Fanning, S. W., Sengupta, S., Fan, P., Curpan, R. F., Rincon, D. M. Q., Greenland, J. A., Rajan, S. S., Greene, G. L. & Craig Jordan, V., Aug 2018, In : Molecular Pharmacology. 94, 2, p. 812-822 11 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Apoptosis
Breast Neoplasms
Tamoxifen
2 Citations (Scopus)
Estrogens
Apoptosis
Breast Neoplasms
PERK kinase
16 Citations (Scopus)

Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells

Fan, P., Tyagi, A. K., Agboke, F. A., Mathur, R., Pokharel, N. & Jordan, V. C., Dec 1 2018, In : Cell Death Discovery. 4, 1, 15.

Research output: Contribution to journalArticle

Open Access
Endoplasmic Reticulum Stress
NF-kappa B
Estrogens
Apoptosis
Breast Neoplasms

Moving Precision Oncology Forward Amid Myths and Misconceptions

Abderrahman, B. & Craig Jordan, V., Dec 2018, In : JAMA Oncology. 4, 12, p. 1789-1790 2 p.

Research output: Contribution to journalLetter

10 Citations (Scopus)

Rethinking extended adjuvant antiestrogen therapy to increase survivorship in breast cancer

Abderrahman, B. & Jordan, V. C., Jan 2018, In : JAMA Oncology. 4, 1, p. 15-16 2 p.

Research output: Contribution to journalComment/debate

Estrogen Receptor Modulators
Breast Neoplasms
Therapeutics

Steroid receptors in breast cancer

Abderrahman, B. & Jordan, V. C., Jan 1 2018, The Breast: Comprehensive Management of Benign and Malignant Diseases. Elsevier Inc., p. 272-281.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Steroid Receptors
Estrogen Receptors
Breast Neoplasms
Tamoxifen
Estrogens
3 Citations (Scopus)

Successful targeted therapies for breast cancer: The worcester foundation and future opportunities in women's health

Abderrahman, B. & Jordan, V. C., Aug 1 2018, In : Endocrinology. 159, 8, p. 2980-2990 11 p.

Research output: Contribution to journalReview article

Women's Health
Breast Neoplasms
Aromatase Inhibitors
Therapeutics
Standard of Care
5 Citations (Scopus)

Tamoxifen resistance trumped and oral selective estrogen receptor degraders arrive

Jordan, V. C., Aug 1 2018, In : Clinical Cancer Research. 24, 15, p. 3480-3482 3 p.

Research output: Contribution to journalArticle

Tamoxifen
Estrogen Receptors
Co-Repressor Proteins
Breast Neoplasms
3 Citations (Scopus)

Targeting peroxisome proliferator-activated receptor g to increase estrogen-induced apoptosis in estrogen-deprived breast cancer cells

Fan, P., Abderrahman, B., Chai, T. S., Yerrum, S. & Jordan, V. C., Dec 1 2018, In : Molecular cancer therapeutics. 17, 12, p. 2732-2745 14 p.

Research output: Contribution to journalArticle

Peroxisome Proliferator-Activated Receptors
Estrogens
pioglitazone
MCF-7 Cells
Apoptosis
1 Citation (Scopus)

Telling details of breast-cancer recurrence

Abderrahman, B. & Jordan, V. C., Jan 11 2018, In : Nature. 553, 7687, 1 p.

Research output: Contribution to journalLetter

Breast Neoplasms
Recurrence
4 Citations (Scopus)

The Study of Letrozole Extension (SOLE) revisited

Jordan, V. C., Feb 1 2018, In : The lancet oncology. 19, 2, p. e77

Research output: Contribution to journalLetter

letrozole
2017
3 Citations (Scopus)

Angela M. Hartley Brodie (1934-2017)

Abderrahman, B. & Jordan, V. C., Aug 2 2017, In : Nature. 548, 7665, 1 p.

Research output: Contribution to journalArticle

21st Century History
20th Century History
Androstadienes
Benzimidazoles
Aromatase Inhibitors
1 Citation (Scopus)

Breast cancer prevention trumps cure

Abderrahman, B. & Craig Jordan, V., Jan 2017, In : Clinical Pharmacist. 9, 1

Research output: Contribution to journalArticle

Breast Neoplasms

Chemoprevention in British women is inadequate

Abderrahman, B. & Craig Jordan, V., Apr 2017, In : Clinical Pharmacist. 9, 4

Research output: Contribution to journalShort survey

Chemoprevention
1 Citation (Scopus)
Aromatase Inhibitors
Breast Neoplasms
Health
Therapeutics
2 Citations (Scopus)

Endoxifen: The end, or are we at the beginning?

Jordan, V. C., Oct 20 2017, In : Journal of Clinical Oncology. 35, 30, p. 3378-3379 2 p.

Research output: Contribution to journalEditorial

4-hydroxy-N-desmethyltamoxifen

ER

Sweeney, E. E. & Jordan, V. C., Jan 1 2017, Cancer Therapeutic Targets. Springer New York, Vol. 2-2. p. 997-1006 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tamoxifen
Estrogen Receptors
Tumors
Breast Neoplasms
Selective Estrogen Receptor Modulators
2 Citations (Scopus)

Long-term adjuvant tamoxifen therapy and decreases in contralateral breast cancer

Abderrahman, B. & Jordan, V. C., Feb 1 2017, In : JAMA Oncology. 3, 2, p. 163-164 2 p.

Research output: Contribution to journalEditorial

Tamoxifen
Breast Neoplasms
Therapeutics
1 Citation (Scopus)

Opportunities and challenges of long term anti-estrogenic adjuvant therapy: treatment forever or intermittently?

Bhattacharya, P., Abderrahman, B. & Jordan, V. C., Apr 3 2017, In : Expert Review of Anticancer Therapy. 17, 4, p. 297-310 14 p.

Research output: Contribution to journalArticle

Estrogen Receptors
Estrogens
Breast Neoplasms
Recurrence
Therapeutics
1 Citation (Scopus)

Tamoxifen decreases mortality, but how?

Bhattacharya, P., Abderrahman, B. & Jordan, V. C., Jan 20 2017, In : Journal of Clinical Oncology. 35, 3, 1 p.

Research output: Contribution to journalLetter

Tamoxifen
Mortality
2 Citations (Scopus)

The 4Ps of breast cancer chemoprevention: Putting proven principles into practice

Jordan, V. C., Apr 2017, In : Cancer Prevention Research. 10, 4, p. 219-222 4 p.

Research output: Contribution to journalReview article

Chemoprevention
Tamoxifen
Breast Neoplasms
Preventive Medicine
Heart Neoplasms
2016

A Raloxifene Withdrawal Response: Translational Research, Definitions, and Clinical Applications

Jordan, V. C., Sep 1 2016, In : Integrative cancer therapies. 15, 3, p. 242-244 3 p.

Research output: Contribution to journalEditorial

Translational Medical Research
Raloxifene Hydrochloride
3 Citations (Scopus)

A retrospective: On clinical studies with 5-fluorouracil

Jordan, V. C., Feb 15 2016, In : Cancer research. 76, 4, p. 767-768 2 p.

Research output: Contribution to journalComment/debate

Fluorouracil
Retrospective Studies
Clinical Studies

Assessing the safety of hormonal replacement therapy

Abderrahman, B. & Jordan, V. C., Nov 1 2016, In : Clinical Pharmacist. 8, 11

Research output: Contribution to journalArticle

Progesterone Congeners
Estrogens
Breast Neoplasms
Safety
Therapeutics
2 Citations (Scopus)

Differing perspectives on breast cancer chemoprevention

Jordan, V. C., Feb 2016, In : JAMA Oncology. 2, 2, 1 p.

Research output: Contribution to journalLetter

Anticarcinogenic Agents
Chemoprevention
Tamoxifen
Breast Neoplasms
1 Citation (Scopus)

Estrogen deprivation therapy in ovarian cancer: An opportunity

Abderrahman, B. & Jordan, V. C., Aug 1 2016, In : Journal of Clinical Oncology. 34, 22, p. 2675-2676 2 p.

Research output: Contribution to journalLetter

Ovarian Neoplasms
Estrogens
Therapeutics
6 Citations (Scopus)

Improving long-term adjuvant anti-oestrogenic therapy for breast cancer

Abderrahman, B. & Jordan, V. C., Jun 2016, In : Clinical Pharmacist. 8, 6

Research output: Contribution to journalArticle

Aromatase Inhibitors
Tamoxifen
Breast Neoplasms
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase 6
1 Citation (Scopus)

Is there a role for raloxifene and tamoxifen for the prevention of breast cancer?

Maximov, P. Y. & Jordan, V. C., Jan 1 2016, Trends in Breast Cancer Prevention. Springer International Publishing, p. 83-101 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Tamoxifen
Breast Neoplasms
Selective Estrogen Receptor Modulators
United States Food and Drug Administration
Chemoprevention
7 Citations (Scopus)

Profiles of miRNAs matched to biology in aromatase inhibitor resistant breast cancer

Hoppe, R., Fan, P., Büttner, F., Winter, S., Tyagi, A. K., Cunliffe, H., Craig Jordan, V. & Brauch, H., Jan 1 2016, In : Oncotarget. 7, 44, p. 71235-71254 20 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
MicroRNAs
Breast Neoplasms
Apoptosis
3' Untranslated Regions
4 Citations (Scopus)

Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer

Jordan, V. C., Fan, P., Abderrahman, B., Maximov, P. Y., Hawsawi, Y. M., Bhattacharya, P. & Pokharel, N., Jan 1 2016, In : Discovery Medicine. 21, 117, p. 321-337 17 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Steroids
Hormones
Apoptosis
Breast Neoplasms
5 Citations (Scopus)

Sex steroid induced apoptosis as a rational strategy to treat anti-hormone resistant breast and prostate cancer

Jordan, V. C., Fan, P., Abderrahman, B., Maximov, P. Y., Hawsawi, Y. M., Bhattacharya, P. & Pokharel, N., May 1 2016, In : Discovery Medicine. 21, 117, p. 411-427 17 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Steroids
Hormones
Apoptosis
Breast Neoplasms
4 Citations (Scopus)

The modulation of estrogen-induced apoptosis as an interpretation of the womens health initiative trials

Abderrahman, B. & Jordan, V. C., Jan 2 2016, In : Expert Review of Endocrinology and Metabolism. 11, 1, p. 81-86 6 p.

Research output: Contribution to journalReview article

Conjugated (USP) Estrogens
Women's Health
Medroxyprogesterone Acetate
Estrogens
Apoptosis
2015

Anti-estrogens and selective estrogen-receptor modulators

Fan, P. & Craig Jordan, V., Jan 1 2015, Molecular Oncology: Causes of Cancer and Targets for Treatment. Cambridge University Press, p. 884-892 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Selective Estrogen Receptor Modulators
Estrogens
Estrogen Receptors
Breast Neoplasms
Tamoxifen
17 Citations (Scopus)
Selective Estrogen Receptor Modulators
Estrogen Receptors
Pharmacology
Breast Neoplasms
Neoplasm Metastasis
20 Citations (Scopus)

Inhibition of BET proteins impairs estrogen-mediated growth and transcription in breast cancers by pausing RNA polymerase advancement

Sengupta, S., Biarnes, M. C., Clarke, R. & Jordan, V. C., Jan 1 2015, In : Breast Cancer Research and Treatment. 150, 2, p. 265-278 14 p.

Research output: Contribution to journalArticle

DNA-Directed RNA Polymerases
Estrogens
Estrogen Receptors
Breast Neoplasms
Transcriptional Activation
17 Citations (Scopus)

Integration of downstream signals of insulin-like growth factor-1 receptor by endoplasmic reticulum stress for estrogen-induced growth or apoptosis in breast cancer cells

Fan, P., Cunliffe, H. E., Maximov, P. Y., Agboke, F. A., McDaniel, R. E., Zou, X., Ramos, P., Russell, M. L. & Jordan, V. C., Oct 2015, In : Molecular Cancer Research. 13, 10, p. 1367-1376 10 p.

Research output: Contribution to journalArticle

Somatomedin Receptors
Endoplasmic Reticulum Stress
JNK Mitogen-Activated Protein Kinases
Estrogens
Apoptosis
19 Citations (Scopus)

Obesity and male breast cancer: Provocative parallels?

Humphries, M. P., Jordan, V. C. & Speirs, V., Jun 4 2015, In : BMC medicine. 13, 1, 134.

Research output: Contribution to journalArticle

Male Breast Neoplasms
Obesity
Incidence
Epidemiologic Studies
Public Health
1 Citation (Scopus)

Progesterone and synthetic progestin controversies

Jordan, V. C., Maximov, P. Y. & Fan, P., Oct 2015, In : JAMA Oncology. 1, 7, p. 986-987 2 p.

Research output: Contribution to journalLetter

Progesterone Congeners
Conjugated (USP) Estrogens
Medroxyprogesterone Acetate
Estrogen Replacement Therapy
Progesterone
8 Citations (Scopus)
Hormonal Antineoplastic Agents
Animal Disease Models
Translational Medical Research
Tamoxifen
Animal Models
17 Citations (Scopus)

The molecular, cellular and clinical consequences of targeting the estrogen receptor following estrogen deprivation therapy

Fan, P., Maximov, P., Curpan, R. F., Abderrahman, B. & Jordan, V. C., Dec 15 2015, In : Molecular and cellular endocrinology. 418, p. 245-263 19 p.

Research output: Contribution to journalReview article

Estrogen Receptors
Estrogens
Apoptosis
Breast Neoplasms
Therapeutics
74 Citations (Scopus)

The new biology of estrogen-induced apoptosis applied to treat and prevent breast cancer

Jordan, V. C., Feb 1 2015, In : Endocrine-Related Cancer. 22, 1, p. R1-R31

Research output: Contribution to journalReview article

Estrogens
Apoptosis
Breast Neoplasms
Estrogen Replacement Therapy
Estrogen Receptors
2014
5 Citations (Scopus)

A(nother) scientific strategy to prevent breast cancer in postmenopausal women by enhancing estrogen-induced apoptosis?

Craig Jordan, V., Jan 1 2014, In : Menopause. 21, 10, p. 1160-1164 5 p.

Research output: Contribution to journalReview article

Conjugated (USP) Estrogens
Women's Health
Estrogens
Apoptosis
Breast Neoplasms
15 Citations (Scopus)
Selective Estrogen Receptor Modulators
Tamoxifen
Cells
Breast Neoplasms
Pressure